Preferred Name

Collapsing methods

Synonyms
Definitions

A method whereby data on several variants are "collapsed" into a single covariate based on regions such as genes. Genome-wide association studies (GWAS) analyse a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. Traditional association techniques can lack the power to detect the significance of rare variants individually, or measure their compound effect (rare variant burden). "Collapsing methods" were developed to overcome these problems.

ID

http://edamontology.org/operation_3791

comment

Genome-wide association studies (GWAS) analyse a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. Traditional association techniques can lack the power to detect the significance of rare variants individually, or measure their compound effect (rare variant burden). "Collapsing methods" were developed to overcome these problems.

Created in

1.17

hasDefinition

A method whereby data on several variants are "collapsed" into a single covariate based on regions such as genes.

inSubset

http://edamontology.org/bio

http://edamontology.org/operations

label

Collapsing methods

prefixIRI

operation_3791

prefLabel

Collapsing methods

subClassOf

http://edamontology.org/operation_3197

Delete Subject Author Type Created
No notes to display