Preferred Name

Protein folds and structural domains

Synonyms

Protein folds

Protein membrane regions

Intramembrane regions

Protein topological domains

Protein structural domains

Protein transmembrane regions

Protein domains

Transmembrane regions

Definitions

Protein tertiary structural domains and folds in a protein or polypeptide chain. This includes topological domains such as cytoplasmic regions in a protein. This includes trans- or intra-membrane regions of a protein, typically describing physicochemical properties of the secondary structure elements. For example, the location and size of the membrane spanning segments and intervening loop regions, transmembrane region IN/OUT orientation relative to the membrane, plus the following data for each amino acid: A Z-coordinate (the distance to the membrane center), the free energy of membrane insertion (calculated in a sliding window over the sequence) and a reliability score. The z-coordinate implies information about re-entrant helices, interfacial helices, the tilt of a transmembrane helix and loop lengths.

ID

http://edamontology.org/topic_0736

comment

This includes topological domains such as cytoplasmic regions in a protein.

This includes trans- or intra-membrane regions of a protein, typically describing physicochemical properties of the secondary structure elements. For example, the location and size of the membrane spanning segments and intervening loop regions, transmembrane region IN/OUT orientation relative to the membrane, plus the following data for each amino acid: A Z-coordinate (the distance to the membrane center), the free energy of membrane insertion (calculated in a sliding window over the sequence) and a reliability score. The z-coordinate implies information about re-entrant helices, interfacial helices, the tilt of a transmembrane helix and loop lengths.

Created in

beta12orEarlier

hasDefinition

Protein tertiary structural domains and folds in a protein or polypeptide chain.

hasHumanReadableId

Protein_folds_and_structural_domains

hasNarrowSynonym

Protein folds

Protein membrane regions

Intramembrane regions

Protein topological domains

Protein structural domains

Protein transmembrane regions

Protein domains

Transmembrane regions

inSubset

http://edamontology.org/bio

http://edamontology.org/topics

isdebtag

true

label

Protein folds and structural domains

prefixIRI

topic_0736

prefLabel

Protein folds and structural domains

seeAlso

https://en.wikipedia.org/wiki/Protein_superfamily

subClassOf

http://edamontology.org/topic_2814

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